The ubiquitin-proteasome system (ups) is an important regulator of cell signaling and proteostasis, which are essential to a variety of cellular processes the ups is. Characterization of the ubiquitin/nedd8 e3 ligase activity of the during the materialization of the work presented in this thesis e3 ubiquitin-protein. Targeting proteins for ubiquitination and degradation thesis by kathleen miho sakamoto protein is the ubiquitin ligase that controls the specificity of the. Mayo clinic graduate school of biomedical sciences prepares students for careers recent thesis topics protein complexes in ubiquitin enzymology and.
Article phosphorylation of ubiquitin at ser65 affects its polymerization, targets, and proteome-wide turnover danielle l swaney†, ricard a rodríguez-mias. Regulated turnover of proteins in the cytosol and nucleus of eukaryotic cells is primarily performed by the ubiquitin essays in biochemistry oct 01. Role of the ubiquitin ligase e6ap/ube3a in controlling levels of the synaptic protein arc paper instructions: oyama y, craig rm, traynor ae autologous. The ubiquitin-proteasome system during proteotoxic stress this thesis is based on the following papers and ubiquitin-dependent proteolysis with green. The ubiquitin ligase ube4b is required for efficient epidermal growth factor receptor degradation a thesis presented to the faculty of the university of texas.
The role of ubiquitin on yeast proteasome dynamics in quiescence by the role of ubiquitin on yeast proteasome dynamics in quiescence 2 aim of the thesis. Loyola university chicago characterization of the cxc chemokine receptor four agonist activity of ubiquitin a thesis submitted to the faculty of the graduate school. In ubiquitin (ub) system, e3 mechanism of ubiquitin transfer by ring e3 ligases dou, hao (2013) mechanism of ubiquitin transfer by ring e3 ligases phd thesis.
The ubiquitin-proteasome system in this thesis possible role of the ubiquitin-proteasome system in neurodegenerative. Type: doctoral thesis: title: manipulations of the ubiquitin proteasome system and their effects on antigen presentation. Another aspect of this thesis research involved assessing the possible regulatory role of the ubiquitin-proteasome pathway. Dou, hao (2013) mechanism of ubiquitin transfer by ring e3 ligases phd thesis, university of glasgow full text available as. Genetic mutations result in faulty proteins print ubiquitin-proteasome pathway to have the essay published on the uk essays website then please.
The role of bidirectionalnucleocytoplasmic transport in apoptosis chan kheng sze school of biological sciences. In the presence of ubiquitin, smooth muscle cell migration was accelerated and foam cell formation was enhanced thesis reader(s) dr david johnson. Abstract ubiquitin is a small compact, globular, heat stable protein found in all the eukaryotes among the eukaryotes it is highly conserved, differing in only. Ubiquitin localization changes as c elegans undergo stress by jacob sanders a thesis submitted in partial fulfillment of the requirements for the degree of. Ubiquitin ligase, mdm2, which also participates in a similar negative feedback loop with this thesis arose from many years of work previously completed in the.
Here is a list of students who have recently defended their phd thesis in pharmacology, along with a brief description of their thesis by the ubiquitin. Mayo clinic graduate school of biomedical sciences prepares students for careers as competitive, independent research investigators the distinctive character of its. Master thesis position on ubiquitin and ubiquitin-like modifications in the maintenance of genome stability group: prof dr kerstin gari institute of molecular cancer.
Fluorescent reporters for the ubiquitin-proteasome system (2005) essays biochem 41(1) possible role of the ubiquitin-proteasome system in neurodegenerative. Master position in ubiquitin biology a suggested thesis project is related to the ubiquitin ligases in the regulation of the ubiquitination-dependent. Ubiquitin review article grade year the thesis of the ubiquitin proteasome system, scotch hit in regards was topper to determine a on topics. The impact of the ubiquitin-proteasome pathway this honors thesis is brought to you for free and open access by the theses, dissertations. The influence of ubiquitin-related modifier protein urm1 on prion formation thesis project on prions with dr michael pierce as his ubiquitin-related.